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The New England Journal of Medicine (NEJM) RSS feed -- current issue. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice
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Trajectories of Disability in the Last Year of Life

Mié, 07/14/2010 - 20:55

To the Editor: In their study identifying five potentially useful trajectories of disability in activities of daily living during the ...

Advance Directives and Surrogate Decision Making before Death

Mié, 07/14/2010 - 20:55

To the Editor: In their Special Article on advance directives, Silveira et al. (April 1 issue)1 recommend the continued use ...

Are All Readmissions Bad Readmissions?

Mié, 07/14/2010 - 20:55

To the Editor: The Centers for Medicare and Medicaid Services (CMS) view readmission for any reason after an index hospitalization ...

Hepatitis B Virus Infection

Mié, 07/14/2010 - 20:55

Hepatitis B Virus Infection . There were several errors in Table 1 (page 1490): in the "Serum HBV DNA undetectable by PCR" row, the value given in the Tenofovir column ...

Pancreatic Cancer

Mié, 07/14/2010 - 20:55

Pancreatic Cancer . In the second paragraph (page 1605), the third sentence should have begun, "The risk of pancreatic cancer in smokers is 2.5 to 3.6 times that in nonsmokers ...

Oral Cladribine and Fingolimod for Relapsing Multiple Sclerosis

Mié, 07/14/2010 - 20:55

Oral Cladribine and Fingolimod for Relapsing Multiple Sclerosis . In the letter to the Editor from Li and Zhang (page 1739), the first reference cited should have been "Polman CH, ...

CME: Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis

Mié, 07/14/2010 - 20:55
(No abstract is available for this citation)

CME: Effects of Medical Therapies on Retinopathy Progression in Type 2 Diabetes

Mié, 07/14/2010 - 20:55
(No abstract is available for this citation)

CME: Acute Pulmonary Embolism

Mié, 07/14/2010 - 20:55
(No abstract is available for this citation)

Don't Forget Tobacco

Mié, 07/14/2010 - 20:55

At a time when all eyes are focused on health care reform, escalating medical costs, and childhood obesity, cigarette smoking remains by far the most common cause of preventable death ...

The Havasupai Indian Tribe Case -- Lessons for Research Involving Stored Biologic Samples

Mié, 07/14/2010 - 20:55

On April 20, 2010, Arizona State University (ASU) agreed to pay $700,000 to 41 members of the Havasupai Indian tribe to settle legal claims that university researchers improperly used tribe ...

Becoming a Physician: The Case for Primary Care -- A Medical Student's Perspective

Mié, 07/14/2010 - 20:55

Ms. J. was no stranger to medical students. The year before I came along, she'd worked with another student, and she took unabashed pleasure in sharing the teachable complexities of ...

Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis

Mié, 07/14/2010 - 20:55
A standard glucocorticoid regimen plus rituximab was not superior to standard intravenous cyclophosphamide as induction therapy in patients with newly diagnosed antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and renal involvement. Rates of sustained remission were high in both groups.

Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis

Mié, 07/14/2010 - 20:55
This multicenter, randomized, double-blind, double-dummy, noninferiority trial compared rituximab with cyclophosphamide for remission induction in ANCA-associated vasculitis. Rituximab therapy was not inferior to daily cyclophosphamide treatment for remission induction in severe ANCA-associated vasculitis and may be superior in relapsing disease.

Effects of Medical Therapies on Retinopathy Progression in Type 2 Diabetes

Mié, 07/14/2010 - 20:55
Patients with type 2 diabetes mellitus were evaluated for progression of diabetic retinopathy after being randomly assigned to receive several medical therapies. At 4 years, the rate of progression was significantly lower with intensive glycemia therapy than with standard glycemia therapy and significantly lower with simvastatin plus fenofibrate than with simvastatin plus placebo.

Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management

Mié, 07/14/2010 - 20:55
In this trial, obese or overweight adults were randomly assigned to receive the selective serotonin 2C receptor agonist lorcaserin or placebo for 52 weeks, along with diet and exercise counseling. Lorcaserin use, in conjunction with behavioral modification, was associated with significant weight loss, improved maintenance of weight loss, and improved levels of cardiovascular biomarkers.

Early versus Standard Antiretroviral Therapy for HIV-Infected Adults in Haiti

Mié, 07/14/2010 - 20:55
The optimal time to initiate antiretroviral therapy in HIV-infected adults, especially in resource-poor areas, is debated. In this study of HIV-infected adults in Haiti, the investigators found that when antiretroviral therapy was initiated when the CD4 count was greater than 200 and less than 350 per cubic millimeter, as compared with waiting until the CD4 count fell to 200 per cubic millimeter or less, the rate of death was decreased, as was the rate of incident tuberculosis.

Current Concepts: Acute Pulmonary Embolism

Mié, 07/14/2010 - 20:55
Pulmonary embolism should be suspected in all patients who present with new or worsening dyspnea, chest pain, or sustained hypotension without a clear alternative cause. This review focuses on the optimal diagnostic strategy and management, according to the clinical presentation.

Schnyder's Crystalline Corneal Dystrophy

Mié, 07/14/2010 - 20:55

A 30-year-old Asian Indian woman with no medical history presented with blurry vision in both eyes. The patient reported that white spots in her eyes had been enlarging over the ...

Paget-Schroetter Syndrome

Mié, 07/14/2010 - 20:55

A 47-year-old woman with no medical history presented with swelling, pain, and reddish discoloration of the right arm and hand after strenuous effort. Findings on ultrasonography, computed tomography, and magnetic ...